Patents

1. Harshil Dave, Hitasha Vithalani, Mukesh Dhanka*, INJECTABLE HYDROGEL AND A PROCESS FOR ITS PREPARATION. Indian Patent No. 566185, Granted, 2025. (Application No. 202421066983)

Publications

1. Meena, M., Yadav, I., Gajjar, D., Joshi, A., Seshadri, S. and Dhanka, M., 2025. “Zingerone Nanoparticle-Embedded Laponite–Natural Gum based Injectable Hydrogel for Fast Track Wound Repair”. Colloids and Surfaces A: Physicochemical and Engineering Aspects, p.137349. DOI: https://doi.org/10.1016/j.colsurfa.2025.137349
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2. Laxmanan, K., Yadav, I., Kumari, P.B., Meena, M., Kang, H.W. and Dhanka, M., 2025. “Structurally Interlinked Multi-Crosslinking Bioactive Hydrogel Network with Enhanced Antioxidant, Antibiofilm, and Antibacterial Functionalities”. Materials Today Communications, p.112936. DOI: https://doi.org/10.1016/j.mtcomm.2025.112936
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3. Dan, A., Singh, H., Shah, T.K., Sheikh, W.M., Shafi, M., Karthikeyan, L., Jan, J., Hassan, S., Bashir, S.M. and Dhanka, M., 2025. “Injectable self-healing dynamic aldehyde-gellan gum-based hydrogel nanocomposite with enhanced antibacterial and antioxidant wound dreto alleviate chronic skin wound”. Journal of Drug Delivery Science and Technology, p.107075. DOI: https://doi.org/10.1016/j.jddst.2025.107075ssing
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4. Darban, Z., Sheikh, W.M., Singh, H., Dan, A., Garia, H., Iqbal, A., Abeer, I., Gaur, R., Hassan, S., Dhanka, M. and Bashir, S.M., 2025. “Chemically engineered nanoceria-vancomycin enriched multifaceted hydrogel for combatting deep wounds: Insights from preclinical research”. Materials Today Chemistry, 45, p.102615. DOI: https://doi.org/10.1016/j.mtchem.2025.102615
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5. Kuddushi, M., Vithalani, H., Singh, H., Dave, H., Jain, A., Pal, A., Kumar, S., Bhatia, Z., Seshadri, S. and Dhanka, M., 2025. Easily Injectable, Organic Solvent‐Free Self‐Assembled Hydrogel Platform for Endoscope Mediated Gastrointestinal Polypectomy. Advanced Healthcare Materials, 14(9), p.2403915. DOI: https://doi.org/10.1002/adhm.202403915
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6. Dave, H., Vithalani, H., Singh, H., Yadav, I., Jain, A., Pal, A., Patidar, N., Navale, A. and Dhanka, M., 2025. Amphiphilic Gelator‐Based Shear‐Thinning Hydrogel for Minimally Invasive Delivery via Endoscopy Catheter to Remove Gastrointestinal Polyps. Small, 21(8), p.2405508. DOI: https://doi.org/10.1002/smll.202405508
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7. Vithalani, H., Dave, H., Singh, H., Sharma, D., Navale, A. and Dhanka, M., 2025. Mechanically robust, mouldable, dynamically crosslinked hydrogel flap with multiple functionalities for accelerated deep skin wound healing. Biomaterials Advances, p.214195. DOI: https://doi.org/10.1016/j.bioadv.2025.214195 ​​
8. Dan, A., Sharma, D., Singh, H., Kumar, S., Bhatia, Z., Hassan, S., Seshadri, S. and Dhanka, M., 2025. A dynamically crosslinked, self-adapting, injectable gelatin–chondroitin sulfate hydrogel with antibacterial and antioxidant properties for treatment of deep and irregular wounds. Journal of Materials Chemistry B. DOI: https://doi.org/10.1039/D4TB02537G
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9. Dan, A., Panigrahi, A., Singh, H., Murali, V., Meena, M., Goyel, P., Laxmanan, K., Misra, S., Varghese, N., Babu, S.S. and Dalvi, Y.B., 2025. Engineering a bacterial polysaccharide-based Metal-organic framework enhanced bioactive 3D hydrogel for accelerated full-thickness wound healing. Biomaterials Science. DOI: https://doi.org/10.1039/D5BM00133A
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10. Verma, A., Kumar, P., Kuddushi, M., Joshi, G., Khatua, S., Dhanka, M. and Chauhan, D.S., 2025. Advancements in nanosensors for an early detection of cancer. In Nanosensors in Healthcare Diagnostics (pp. 117-149). Academic Press. DOI: https://doi.org/10.1016/B978-0-443-19129-9.00006-6
11. Dave, H., Vithalani, H., Singh, H., Yadav, I., Jain, A., Kumar, S., Bhatia, Z., Seshadri, S., Hassan, S. and Dhanka, M., 2024. Easily injectable gelatin-nonanal hydrogel for endoscopic resectioning of gastrointestinal polyps. International Journal of Biological Macromolecules, 279, p.135405. DOI: https://doi.org/10.1016/j.ijbiomac.2024.135405
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12. Singh, H., Dan, A., Kumari, B.P., Dave, H., Parsaila, N., Navale, A., Darban, Z., Yadav, I., Goyal, P., Misra, S.K. and Shahabuddin, S., 2024. Copper-MOF and tannic acid-empowered composite cryogel as a skin substitute for accelerated deep wound healing. Biomaterials Advances, 164, p.213983. DOI: https://doi.org/10.1016/j.bioadv.2024.213983
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13. Jain, N.K., Pallod, S., Peng, B., Kumari, R., Chauhan, D.S., Dhanka, M., Aung Win, E.H., Teitell, M.A., Chandra, P., Srivastava, R. and Prasad, R., 2024. Stimuli Responsive Molecular Exchange of Structure Directing Agents on Gold Nanobipyramids: Cancer Cell Detection and Synergistic Therapeutics. ACS Applied Bio Materials, 7(7), pp.4542-4552. DOI: https://pubs.acs.org/doi/10.1021/acsabm.4c00409?goto=supporting-info
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14. Singh, P., Singh, H., Upadhyay, S., Dan, A., Dhanka, M. and Saha, J., 2024, June. Green chemistry-induced carbon nanoparticles with antioxidant and antibacterial assay. In Biomedical Spectroscopy, Microscopy, and Imaging III (Vol. 13006, pp. 137-143). SPIE. DOI: https://doi.org/10.1117/12.3021289
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15. Singh, H., Dhanka, M., Yadav, I., Gautam, S., Bashir, S.M., Mishra, N.C., Arora, T. and Hassan, S., 2024. Technological interventions enhancing curcumin bioavailability in wound-healing therapeutics. Tissue Engineering Part B: Reviews, 30(2), pp.230-253. DOI: https://doi.org/10.1089/ten.teb.2023.0085
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16. Vahora, A., Singh, H., Dan, A., Puthenpurackel, S.S., Mishra, N.C. and Dhanka, M., 2024. Nanoengineered oxygen-releasing polymeric scaffold with sustained release of dexamethasone for bone regeneration. Biomedical Materials, 19(3), p.035007. DOI: 10.1088/1748-605X/ad2c17
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17. Singh, H., Kuddushi, M., Singh, R., Sathapathi, S., Dan, A., Mishra, N.C., Bhatia, D. and Dhanka, M., 2024. Functional Biomaterials for Targeted Drug Delivery Applications. In Functional Smart Nanomaterials and Their Theranostics Approaches (pp. 33-64). Singapore: Springer Nature Singapore. DOI: https://doi.org/10.1007/978-981-99-6597-7_2
18. Singh, P., Dan, A., Kannan, P.P., Dhanka, M., Bhatia, D. and Saha, J., 2024. Non-toxic fabrication of fluorescent carbon nanoparticles from medicinal plants/sources with their antioxidant assay. arXiv preprint arXiv:2401.10673. DOI: https://doi.org/10.48550/arXiv.2401.10673
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19. Solanki, R., Dhanka, M., Thareja, P. and Bhatia, D., 2024. Self-healing, injectable chitosan-based hydrogels: structure, properties and biological applications. Materials Advances, 5(13), pp.5365-5393. DOI: https://doi.org/10.1039/D4MA00131A ​​
20. Singh, N., Singh, A., Dhanka, M. and Bhatia, D., 2024. DNA functionalized programmable hybrid biomaterials for targeted multiplexed applications. Jounal of Materials Chemistry B, 12(30), pp.7267-7291. DOI: https://doi.org/10.1039/D4TB00287C ​​
21. Singh, H., Hassan, S., Nabi, S.U., Mishra, N.C., Dhanka, M., Purohit, S.D., Ganai, N.A., Bhaskar, R., Han, S.S., Qurashi, A.U.H. and Bashir, S.M., 2024. Multicomponent decellularized extracellular matrix of caprine small intestine submucosa based bioactive hydrogel promoting full-thickness burn wound healing in rabbits. International Journal of Biological Macromolecules, 255, p.127810. DOI: https://doi.org/10.1016/j.ijbiomac.2023.127810 ​​
22. Darban, Z., Singh, H., Singh, U., Bhatia, D., Gaur, R., Kuddushi, M., Dhanka, M. and Shahabuddin, S., 2024. β-Carotene laden antibacterial and antioxidant gelatin/polyglyceryl stearate nano-hydrogel system for burn wound healing application. International Journal of Biological Macromolecules, 255, p.128019. DOI:https://doi.org/10.1016/j.ijbiomac.2023.128019
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23. Singh, H., Dan, A., Kumawat, M.K., Pawar, V., Chauhan, D.S., Kaushik, A., Bhatia, D., Srivastava, R. and Dhanka, M., 2023. Pathophysiology to advanced intra-articular drug delivery strategies: Unravelling rheumatoid arthritis. Biomaterials, 303, p.122390. DOI: https://doi.org/10.1016/j.biomaterials.2023.122390 ​​
24. Singh, H., Hassan, S., Nabi, S.U., Mishra, N.C., Dhanka, M., Purohit, S.D., Ganai, N.A., Bhaskar, R., Han, S.S., Qureshi, A.U.H. and Bashir, S.M., 2023. Multicomponent bioactive hydrogel promoting full-thickness burn wound healing in rabbits. International Journal of Biological Macromolecules, pp.127810-127810. DOI:https://doi.org/10.1016/j.ijbiomac.2023.127810
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25. Singh, H., Yadav, I., Sheikh, W.M., Dan, A., Darban, Z., Shah, S.A., Mishra, N.C., Shahabuddin, S., Hassan, S., Bashir, S.M. and Dhanka, M., 2023. Dual cross-linked gellan gum/gelatin-based multifunctional nanocomposite hydrogel scaffold for full-thickness wound healing. International Journal of Biological Macromolecules, 251, p.126349. DOI: https://doi.org/10.1016/j.ijbiomac.2023.126349
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26. Das, S.S., Sharma, D., Rao, B.V.K., Arora, M.K., Ruokolainen, J., Dhanka, M., Singh, H. and Kesari, K.K., 2023. Natural cationic polymer-derived injectable hydrogels for targeted chemotherapy. Materials Advances, 4(23), pp.6064-6091. DOI:https://doi.org/10.1039/D3MA00484H
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27. Jain, N.K., Mehta, J.M., Palaniappan, A., Dhanka, M., Prasad, R. and Srivastava, R., 2023. Metal and carbon nanocarriers for potential delivery of plant-based active ingredients. In Nanotechnology in Herbal Medicine (pp. 425-446). Woodhead Publishing. DOI: https://doi.org/10.1016/B978-0-323-99527-6.00002-1
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28. Singh, H., Singh, R., Dan, A., Vithalani, H., Das, S.S., Fernando, A.V., Vankayala, R., Bhatia, D. and Dhanka, M., 2023. Bioconjugated materials as potential vehicles for delivery of antibiotics/drugs. In Comprehensive Analytical Chemistry (Vol. 103, pp. 29-58). Elsevier. DOI: https://doi.org/10.1016/bs.coac.2023.03.003
29. Dhayani, A., Srinath, P., Prasad, S.E., Naaz, A., Dhanka, M., Kalita, S. and Vemula, P.K., 2022. Function-Inspired design of molecular hydrogels: paradigm-shifting biomaterials for biomedical applications. Molecular Architectonics and Nanoarchitectonics, pp.209-232. DOI: https://link.springer.com/chapter/10.1007/978-981-16-4189-3_9 ​​
30. Sunnapu, O., Khader, R., Dhanka, M., Kumar Vemula, P. and Karuppannan, S., 2022. Enzyme‐responsive hydrogel for delivery of the anti‐inflammatory agent zingerone. ChemNanoMat, 8(11), p.e202200334. DOI: https://doi.org/10.1002/cnma.202200334
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31. Omprakash Sunnapu,Rajamohammed Khader,Mukesh Dhanka,Praveen Kumar Vemula,Sekar Karuppannan,Enzyme-Responsive Hydrogel for Delivery of the Anti-Inflammatory Agent Zingerone, ChemNanoMat, 2022. DOI: doi.org/10.1002/cnma.202200334

2025

Prof. Mukesh Dhanka, along with PhD scholars Hitasha Vithalani and Harshil Dave, has developed a novel class of multifunctional stretchable hydrogels designed for advanced wound healing applications. This significant research breakthrough was recently featured in Gujarat Samachar, recognizing the innovation’s potential to transform modern wound care therapy.

2024

Prof. Mukesh Dhanka and PhD scholars Harshil Dave and Hitasha Vithalani along with post-doctoral fellow Dr. Hemant Singh and Dr. Indu Yadav developed advanced injectable hydrogels for gastrointestinal cancer detection and treatment. This breakthrough, focusing on plant-based, biocompatible hydrogels for safer and more effective endoscopic procedures, was prominently featured in The Indian Express.

Happy to share that our research on advanced injectable hydrogels for gastrointestinal cancer detection and treatment was featured in Navjeevan Express. Prof. Dr. Mukesh Dhanka along with PhD scholars Harshil Dave and Hitasha Vithalani developed these plant-based, biocompatible hydrogels to enhance endoscopic procedures and enable disease-responsive drug delivery.

Thrilled to share that our groundbreaking research on injectable hydrogels for gastrointestinal cancer detection and treatment was featured in Ahmedabad Mirror. The innovative hydrogel, developed by our research scholars Harshil Dave, and Hitasha Vithalani, provides a safer, biocompatible, and economical solution for endoscopic procedures. This 'cushion-like' material holds promise for enhancing cancer care and reducing treatment complexities.